Trans-Resveratrol

Common Name Resveratrol
Nature Natural polyphenol antioxidant
Scientific Name Trans-Resveratrol (3,5,4′-trihydroxystilbene)
Source Natural
Part Used Skin of grapes and plant extracts (especially Polygonum cuspidatum)
Native Location Asia, Europe, and North America

  • Benefits

    • Antioxidant Protection: Trans-Resveratrol is a potent antioxidant that helps protect cells from oxidative stress caused by free radicals. (1)
    • Cardiovascular Health Support: Resveratrol may help support heart health by promoting healthy blood vessel function and supporting normal circulation. (2) 
    • Healthy Aging Support: Trans-Resveratrol is known to activate sirtuin pathways associated with cellular health and longevity, supporting healthy aging processes. (3)
    • Metabolic Health: Resveratrol may help support metabolic balance and normal glucose metabolism. (4)
    • Anti-Inflammatory Support: Resveratrol may help support a healthy inflammatory response, contributing to overall cellular health. (5)

  • Trans-Resveratrol (3,5,4′-trihydroxystilbene)

    Trans-Resveratrol is a naturally occurring polyphenol found in the skin of red grapes, berries, peanuts, and the plant Polygonum cuspidatum (Japanese knotweed). It has gained scientific interest for its potential role in supporting cardiovascular health and healthy aging.

    It functions as a potent antioxidant and cellular signaling compound, known to activate sirtuin enzymes involved in cellular repair, metabolic regulation, and stress response. Due to these properties, trans-resveratrol is widely used in nutraceuticals to support heart health, metabolic balance, and overall wellness. (6)

Scientific Research and Studies

research and science

Cardiovascular Health and Resveratrol

Study Design: A controlled clinical study investigated the effects of resveratrol supplementation on cardiovascular health markers.

Findings: Results indicated that resveratrol supplementation helped improve endothelial function and supported healthy blood vessel activity, contributing to cardiovascular health. (7)

Antioxidant and Cellular Protection

Study Design: Laboratory and human studies evaluated the antioxidant activity of resveratrol and its effects on oxidative stress markers.

Findings: Resveratrol demonstrated strong antioxidant activity and was shown to help reduce oxidative stress while supporting cellular defense systems. (8)

Resveratrol and Healthy Aging

Study Design: Research studies examined the role of resveratrol in activating sirtuin pathways linked to longevity.

Findings: Resveratrol was found to activate SIRT1 enzymes involved in cellular repair and metabolic regulation, suggesting potential benefits for healthy aging and metabolic health. (9)

Resveratrol as a privileged molecule with antioxidant activity

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The Effect of Resveratrol on the Cardiovascular System from Molecular Mechanisms to Clinical Results

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Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial

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Resveratrol role in cardiovascular and metabolic health and potential mechanisms of action

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Anti-Inflammatory Properties of Resveratrol

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An Overview of Trans-Resveratrol

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The effects of resveratrol intervention on risk markers of cardiovascular health

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The Effects of Resveratrol on Oxidative Stress Markers

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Sirtuins, resveratrol and the intertwining cellular pathways connecting them

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  • Disclaimer: The information provided is based on scientific research and general knowledge and none of the above statements are evaluated by FDA or EFSA. This product is not intended to diagnose, treat, cure or prevent any disease.